アイテム番号:
SCP-6009
オブジェクトクラス:
TICONDEROGA
6009-Catena surrounding a neuron (2500x) / 神経細胞を取り巻く6009-Catena(2500倍)
Special Containment Procedures: Due to the necessity of SCP-6009 for biological function, no containment procedure so far has been found to be successful, and is likely impossible and unnecessary. Containment procedure currently focuses on prevention of information leak regarding SCP-6009 and the 6009-Catena region.
特別収容プロトコル: 生物学的機能におけるSCP-6009の必要性により現在まで何らかの収容手順が成功した例は存在しておらず、また収容は不可能かつ不必要であると考えられています。現在の収容手順はSCP-6009および6009-Catena領域に関する情報漏洩の防止に焦点を合わせたものとなっています。
The microscopic size of SCP-6009 and lack of immediately noticeable anomalous traits makes it unlikely a civilian researcher would uncover the anomaly. Publications regarding genetics, epigenetics, microbiology, and neuroscience should be screened for papers pertaining to SCP-6009, under purview of the Nanobiomics Department whether to allow publication.
SCP-6009の大きさが微視的なものであること、および一見して発見可能な異常特性が存在しないことを原因として、民間の研究者が本異常を発見する可能性はほぼ無いものと考えられます。遺伝学、後成学(エピジェネティクス)、微生物学、神経科学に関連する出版物はSCP-6009に関する論文が掲載されていないかをナノバイオミクス部門の管轄で精査し、出版の可否を決定する必要があります。
Medical textbooks have been standardized to include the 6009-Catena region as protective tissue, which can be safely ignored. Because of this, it is unlikely a civilian physician or surgeon would be able to deduce the anomalous nature of 6009-Catena; however, medical journals and case reports of neurosurgery should still be screened for mentions of 6009-Catena or SCP-6009.
医学の教科書には、6009-Catena領域を問題なく無視できる保護組織として述べる内容が織り込まれるように規格が定められています。このため民間の内科医や外科医が推論により6009-Catenaの異常性に辿り着く可能性はまず無いものと推測されますが、医学誌および神経手術の症例報告は依然6009-CatenaあるいはSCP-6009への言及が存在しないかを検査されるべきです。
Genomic data regarding cluster association obtained from Project Vigenère are available upon request for all personnel of Clearance Level 3 and above. All inquiries and testing regarding SCP-6009 are under the jurisdiction of the Nanobiomics Department.
プロジェクト・ヴィジュネルで取得されたクラスター群集のゲノムデータは、請求すればクリアランスレベル3以上のすべての職員が利用可能です。SCP-6009に関する全ての調査・実験はナノバイオミクス部門の管轄下で行われています。
A proposal to reclassify SCP-6009 from Ticonderoga1 to Thaumiel is on hold, pending the results of Project Vigenère.
SCP-6009をTiconderoga2からThaumielへ再分類する提言は、プロジェクト・ヴィジュネルの成果が得られるまで保留されています。
Description: SCP-6009 is the human mitochondrion.
説明: SCP-6009はヒトのミトコンドリアです。
Structurally and functionally, SCP-6009 are largely similar to mitochondria in other eukaryotes, including its role in cellular respiration, cell cycle regulation, and certain signalling pathways. A number of factors differentiate SCP-6009 from mitochondria found in other eukaryotes.
細胞呼吸、細胞周期の制御、特定のシグナル伝達経路における役割を含め、SCP-6009は構造的・機能的には概ねヒト以外の真核生物のミトコンドリアと同様です。SCP-6009は複数の因子において他の真核生物のミトコンドリアと区別されます。
| Category | Non-anomalous mitochondrion | SCP-6009 |
|---|---|---|
| Image | ||
| Physical Size | ~500-1000 nm | ~200-500 nm |
| Motility (in-cell) | Achieved by attaching to the motor/adaptor complex (MIRO1) | Achieved by attaching to the motor/adaptor complex (MIRO1) |
| Motility (out-cell) | No such behavior observed | Observed, mechanism unknown |
| Mitochondria DNA (mtDNA) Size | ~16.5 kbp in animals, ~2 kbp in plants | ~16-18 kbp depending on location |
| Existence Outside of Cells | Rare occasions in the blood stream | See addendum on 6009-Catena |
| Fusion and Fission | Very common | Very common |
| カテゴリー | 非異常のミトコンドリア | SCP-6009 |
|---|---|---|
| 画像 | ||
| 物理的な大きさ | ~500-1000 nm | ~200-500 nm |
| 運動性(細胞内) | モーター-アダプター複合体(MIRO1)と接続することで達成 | モーター-アダプター複合体(MIRO1)と接続することで達成 |
| 運動性(細胞外) | そのような活動は観察されない | 観察されるが、機構は不明 |
| ミトコンドリアDNA(mtDNA)のサイズ | 動物では~16.5 kbp、植物では~2 kbp | ~16-18(位置による) |
| 細胞外での存在 | 血流中にまれにみられる | 6009-Catenaについての補遺を参照 |
| 融合と分裂 | 非常によくみられる | 非常によくみられる |
Addendum - 6009-Catena: The most notable anomaly surrounding SCP-6009 that differentiates it from conventional cell biology is the existence of the 6009-Catena region. SCP-6009 is observed to exist outside of cells and congregate into colony-like structures, and exhibit high levels of motility, the mechanism of which does not conform to motile mechanisms used within the cell. SCP-6009 instances are observed to sometimes fuse into chain-like structures in the 6009-Catena region; this behavior is not observed elsewhere in the body.
The 6009-Catena region is a web of these SCP-6009 chains along the extracellular matrix, found interweaved in between the dendrites and myelinated axons of the brain. The vast majority of SCP-6009 in 6009-Catena surrounds the basal ganglia, but strands of 6009-Catena extend within all areas of the neural circuitry. The vast majority of 6009-Catena does not move much, but the ends of the "ladders" are motile and free-moving, and is believed to used to maintain the shape and connection of the region. Proteins, certain ions, and neurotransmitters flow freely in and out of 6009-Catena and neurons, creating an alternative signaling mechanism to maintain function. While it only constitutes roughly 2% of white matter by mass, it is believed to have a significant role in neurological function and neural circuitry formation.
The anomalous nature of SCP-6009, as differing from other eukaryotes, did not become clear until the discovery of 6009-Catena. As SCP-6009 typically also perish within hours after the death of its host human, posthumous autopsies have not detected SCP-6009 activity in 6009-Catena regions. SCP-6009, within a cultured cell in vitro, behaves exactly the same as non-anomalous mitochondrion, which is why it has eluded researchers for years. SCP-6009 activity is most prevalent within neurons and outside neurons in the 6009-Catena region.
Holistic whole-mitochondrial DNA sequencing3 using ChOMP-Seq revealed an important discrepancy that is the focus of Project Vigenère. The vast majority of mtDNA found in SCP-6009 are well-understood, and codes for non-anomalous proteins such as NADH dehydrogenase, part of regular mitochondrial function. As in regular non-anomalous mitochondria, much of SCP-6009's proteins are synthesized from nuclear genes4. However, where heteroplasmy was thought of as an unintended natural result of mitochondrial replication, it is now believed to be key to SCP-6009 function. The function and distribution of the unknown mitochondrial genes is the subject of Project Vigenère. It is believed that these genes are responsible for the formation of 6009-Catena, as well as other anomalies such as observed motility and interference with neural circuitry.
Much of what has been understood about SCP-6009 was discovered in a collaboration between Dr. Okami Ryōsuke (formerly of the Neuroscience Department) and Dr. Chiang Wei-Huo (formerly of the Genetics Department), both considered founding members of the Nanobiomics Department.
Archived Project Proposal: Filed August 29, 2010 (rejected); September 4, 2010 (rejected); September 8, 2010 (rejected); September 20, 2010 (rejected); October 1, 2010 (accepted)
Cross-Departmental Collaboration Request
| Requester | Originating Department | Target Department | Project Name |
| Chiang Wei-Huo | Genetics Department | Neuroscience Department | - |
Request Details
Preliminary research into the SCP-6009 genome and 6009-Catena has suggested requiring further research. With this collaboration, we hope to understand:
1. The reason and method of motility of SCP-6009: It's been observed to be mobile throughout the body, and is key to how they are able to form 6009-Catena, but the method for extracellular and intercellular movement does not follow the well-understood intracellular motility.
2. The reason and method of 6009-Catena formation: It's clear that because of the role mitochondria play in cell function, there's constant interactions between the 6009-Catena and the neurons it surrounds, but we do not know the details of this interaction. We also might try to investigate if we can find any patterns in how 6009-Catena is formed.
As a crucial element of SCP-6009 is the interaction of 6009-Catena, as well as its association and unknown function, we require expertise in neuroscience to better model 6009-Catena and its possible interaction with the brain.
Archival Addendum: The following communications have been archived pertaining the early research into SCP-6009 from Project Vigenère. Please note that they may contain outdated or inaccurate information.
October 5, 2010
Site-84
Fukuoka, Japan
Greetings Dr. Chiang Wei-Huo,
My name is Okami Ryōsuke, I am a Level 3 Researcher working in Site-84 under the Neuroscience Department. They have assigned me to work with you on your project. I have reviewed the material you sent over about SCP-6009, and your hypothesis regarding the formation of 6009-Catena.
I've been studying neuroscience for a long time and this is the first time I've ever heard of this sort of structure in the brain. So clearly the first question is: How could thousands of scientists have missed this?
I know you submitted a cross-department collaboration request because you think someone in the Neuroscience Department would be able to assist you in modelling 6009-Catena. Conventional MRI and PET scans are enough to map out the white matter in the brain, which is where most of 6009-Catena is attached to, so what needed to be modified? Please elaborate.
Please respond at your briefest convenience.
Okami
October 20, 2010
Site-168
Hsinchu, Taiwan
Dr. Okami,
Good to have you on board! My colleagues at the Genetics Department don’t quite have the same faith in the SCP-6009 project.
I came across 6009-Catena by chance; my team were studying SCP-3966 and found microscopic web-like structures for freshly diseased victims. We thought it was related, but extensive examination on deceased D-Class that was unrelated to SCP-3966 cleared the air. The structure is only visible under TEM5because it's so miniscule, so it was hard to spot, but once you know where to look it's everywhere.
We tried to get it replicated in the lab, it doesn't ever seem to work. And, obviously, mitochondria shouldn’t exist on its own outside of a cell, which is why this whole situation is confusing even without the ladder structure they make.
Based on preliminary fluorescent imaging it's spread throughout the brain's white matter, and has its own connection scheme; they form sort of miniscule nodes at some neural junctions. I don't know neuroscience enough to make any sense of it.
Also based on the imaging, it moves in the body on its own, not by kinesin or any of the usual suspects. It kind of wriggles in and out of the brain, but it's most active in 6009-Catena; it sort of forms a web of nodes. We obviously can't observe it in living human beings, but you can still sort of get a sense of what it does a few hours within a person's death.
I suspect the motility has something to do with the less common genes that have been overlooked because heteroplasmy was thought of as basically genetic junk. That's probably the first thing I should rule out before going onto more wild ideas.
I'm currently trying see if there's any sequencing protocols that can give us that information. Whole-genome sequencing kind of comes close, but it doesn't really quite do the trick, any suggestions?
The two main anomalies of SCP-6009 aren't earth-shattering, but they certainly don't fit any current understanding of chemistry or biology; I think digging deeper into what might be the scientific mechanism how SCP-6009 forms 6009-Catena, we might be able to pinpoint the exact origin?
I think both motility and the Catena formation are intertwined with each other, so hopefully solving one solves the other.
If you aren't interested in the collaboration, it's alright if you decline - you aren't the first person that I've been connected with, I've submitted this collaboration request to the Neuroscience Department a few times. Even the one who originally first saw the web-like structure, Dr. Jenny Hsieh, who also is a neuroscientist, says it isn't worth investigating further, but I think we're onto something.
Chiang
November 12, 2010
Site-84
Fukuoka, Japan
Greetings Dr. Chiang Wei-Huo,
I’m not very well-versed in cell biology, and this might not make sense, but is it possible that the heteroplasmic difference you mentioned in the preliminary report is a possibility of the anomaly that arises from SCP-6009? A paper that I read the other day about how they recently discovered certain introns that are removed during RNA splicing, previously thought to be useless may have a role in mRNA degradation.
Is such a method even possible? I know a single mitochondrion contains hundreds of copies of circular DNA, and accounting for the tiny percentage that is abnormal would be a nightmare. Whole-genome sequencing already handles mitochondrial DNA, so what's your new approach?
I've met Dr. Hsieh a few times, but I am not very familiar with her.
As for the collaboration, I am currently not working on any important projects, so I am intrigued by this proposal.
I'm not entirely convinced that we can do much with SCP-6009. I'm still a bit skeptical, but I'm still happy to collaborate further - does the project have a name?
Please respond at your briefest convenience.
Okami
November 29, 2010
Site-168
Hsinchu, Taiwan
Dr. Okami,
Wonderful! I am very glad to hear someone is finally willing to take on my pet project.
I've named this Project Vigenère, after the cipher - after all, we are decoding a mystery without knowing what's waiting for us in the end! Cryptography fascinates me, but I'm awful at computer science. Genetics is basically biological cryptography anyways.
Anyhow, I've attached some information on how you can see 6009-Catena from brain tissue samples. Haven't found a way to do it in living humans, but hey, that's where you come in!
You should be able to see it once you know what you're looking for; I don't think anyone ever realized such a structure existed within our brains.
Also, please call me Waley! Saying my whole name sounds like I'm some dead politician.
Waley
December 2, 2010
Site-84
Fukuoka, Japan
Waley,
Very well then, nice to meet you. You may call me Ryo.
I followed what you did - quite remarkable, but so delicate! Why did no one want to work on this? This is quite the medical discovery.
Regarding mapping the 6009-Catena region: conventional MRI and PET scans do the trick in mapping white matter, which is where most of where SCP-6009 congregate to form 6009-Catena. I think I'll figure something out with cytoplasmic exclusion so we can get it going.
My colleague, Dr. Michael Aguinaldo, indicates that he may have some idea from his involvement in the early stages of the Khevtuul probe project. The SCP-2669 file is restricted though, so Dr. Aguinaldo says he needs to check in with Director Yamataka for clearance before involving him in our project.
The World Connectome Project just recently released their latest tractography model, but it’s not accurate enough for our purposes and misses out on the inter-neural space where most of 6009-Catena resides. I'll look more into it though.
Do you have MRI machines on your site? Ours just broke, again, so I have to take the train to Osaka every day. Knowing Site-84, it's going to just stay broken forever.
Please respond at your briefest convenience.
Okami
December 28, 2010
Site-168
Hsinchu, Taiwan
Ryo,
That sounds great! Does Dr. Aguinaldo want to join our team?
Here's a rough summary of what I named ChOMP-Seq. It's based off an abandoned side project when we were studying how the genome absorption effect of SCP-2946 worked… didn't think I'd find use for it.
As you can see, a pretty nifty way of sequencing. It seems to work, but because of the parallel sequencing and increased scrutiny during the amplification stage, it gives us a lot of useless data.
I see your site is having problems too… our equipment is fine, but our site has literally only been allotted only four D-class personnel. To run some preliminary comparisons and sequence alignments, I had to take the DNA of some of the junior researchers as well as my own, just so I can see whether ChOMP-Seq actually worked.
Hopefully my request for more D-class goes through, but I doubt it.
Waley
Janurary 5, 2011
Site-84
Fukuoka, Japan
Dear Waley,
I see, that's quite clever.
You're very kind! ChOMP-Seq is a nice and catchy name. I don't know if I feel good about being in the acronym of it though - I only contributed a small suggestion, it was mainly based off of your work and you did all of the testing.
Is there any way for ChOMP-Seq it to output something more standard like FASTQ or VCF, or even just a .txt file? The computers at Site-84 are really outdated and just can't seem to convert or read your custom CSQ files.
Dr. Aguinaldo has other projects he's working on, but he's willing to assist me in shaping up the 6009-Catena model. He got clearance to use his previous work, so we are good! You should now see some Catena networks from D-Class personnel on our drive, check and see if that's what you wanted. Each file is massive, by the way, but that’s unavoidable. The scan takes around twenty minutes, but generating the model afterwards takes our computers all afternoon. Well, it wouldn't need to take all afternoon if my computers weren't from twenty years ago.
Please respond at your briefest convenience.
Okami
出典: SCP-6009(rev.66; 2022/08/07)
著者:Joreth
作成日(EN)： 2021/05/30
SCP-6009 - Powerhouse
SCP-6009 - 力の源
Tags: 6000 _cc _licensebox bacteria biological director-moose doctor-mann esoteric-class genetic microscopic mobile neurological scp species
タグ: en 6000 バクテリア 生物学 ムース管理官 マン博士 esoteric-class 遺伝子 微視的 移動 神経 scp 種族
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